Aspirin Exacerbated Respiratory Disease
Aspirin Exacerbated Respiratory Disease (AERD), also known as Samter’s Triad or aspirin-sensitive asthma, is a chronic medical condition that affects patients with asthma. Patients with AERD present with asthma, recurrent sinus infections and nasal polyps, and sensitivity to aspirin and other anti-inflammatory drugs (NSAIDs).
Usually, the first symptom is nasal inflammation with sneezing, a runny nose, congestion, and often a reduced sense of smell. Later, asthma develops and then the polyps occur inside the nose. Polyps can cause sinusitis, post-nasal drip and obstruction of the airways.
Finally, aspirin sensitivity develops. This can be serious and can trigger asthma attacks and anaphylaxis (an acute whole body allergic reaction). Patients often also react to other aspirin-type anti-inflammatory drugs like Ibuprofen and Naproxen, although acetaminophen is typically safe as long as it is not used in high doses.